Prof. Monty Krieger

Krieger's interests include: cell and molecular biology, lipoprotein receptors, lipoprotein and cholesterol metabolism, atherosclerosis, coronary heart disease, deep vein thrombosis, intracellular protein sorting, golgi function, somatic cell genetics, atherosclerosis, scavenger receptors, pathogen receptors, macrophage physiology, pattern recognition in vertebrate and invertebrate immune systems and female infertility.

Professor Krieger is using genetic, biochemical, physiologic, chemical, cellular and molecular biological methods to study cell surface receptor structure and function. We focus on lipoprotein receptors, in particular the High Density Lipoprotein (HDL) receptor called Scavenger Receptor, Class B, Type I (SR-BI) because of its relevance to many physiological systems and thus to human biology and medicine. The analysis of SR-BI should help provide insights into basic biological processes and contribute to our understanding of atherosclerosis and coronary heart disease (CHD). The risk of developing atherosclerosis is directly related to plasma levels of Low Density Lipoprotein (LDL) cholesterol and inversely related to those of high density lipoprotein (HDL) cholesterol.


(summary updated 2/2013)