Microscopic flows in a biological environment play a remarkable role in regulating human health, from disease causes to driving forces behind diagnostics and therapeutics. Its influence on other living organisms also has far-reaching impact in energy and environment. Such flow-induced dynamic effects, however, are often overlooked in engineering designs due to limitations in existing research toolsets. As a result, conventional biological and medical research face various challenges in accuracy, cost and translational success. In this talk, I will present our group’s work on applying fluid mechanics principles to design biomaterials, cell therapies and pharmacological models. We develop both experimental (in vitro) and computational tools mimicking a dynamic biological flow environment. The combination of these new tools enables us to reduce the use of animal models and shorten the preclinical research timeline while achieving tailor-made design outcomes towards precision medicine.