Biotechnology is poised to enable entirely new manufacturing in the 21st century. The rapid advances in synthetic biology and genome-scale biology are powering new capabilities to make a range of products from basic chemicals to uniquely biologically-enabled products like tissues. Combining these 'front-end' technologies with emerging 'back-end' elements like continuous and integrated operations, automation, and AI/ML can enable new models for accessible biomanufacturing capacity. Growing new capabilities for biomanufacturing could transform the industrial base to enable circular bioeconomies that are both sustainable and prosperous.