Prof. Lindsay Case

Irwin and Helen Sizer Career Development Assistant Professor of Biology

Assistant

Sarah Wylie
smann@mit.edu

Areas of Interest and Expertise

Regulation of Transmembrane Signaling
Focal Adhesions
Cancer Cells
Phase Separation

Research Summary

Professor Case studies how cells regulate the spatial organization of signaling molecules at the plasma membrane to control downstream signaling. For example, receptor clustering and higher-order assembly with cytoplasmic proteins can create compartments with unique biochemical and biophysical properties. Quantitative experimental approaches are used from biochemistry, molecular biophysics, and cell biology to study transmembrane signaling pathways and how they are misregulated in diseases like cancer.

Recent Work