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Prof. Lindsay Case
Irwin and Helen Sizer Career Development Assistant Professor of Biology
Primary DLC
Department of Biology
MIT Room:
68-333A
(617) 253-9430
lcase@mit.edu
https://biology-mit-edu.ezproxy.canberra.edu.au/profile/lindsay-case/
Assistant
Sarah Wylie
(617) 253-9395
smann@mit.edu
Areas of Interest and Expertise
Regulation of Transmembrane Signaling
Focal Adhesions
Cancer Cells
Phase Separation
Research Summary
Professor Case studies how cells regulate the spatial organization of signaling molecules at the plasma membrane to control downstream signaling. For example, receptor clustering and higher-order assembly with cytoplasmic proteins can create compartments with unique biochemical and biophysical properties. Quantitative experimental approaches are used from biochemistry, molecular biophysics, and cell biology to study transmembrane signaling pathways and how they are misregulated in diseases like cancer.
Recent Work
Related Faculty
Dr. Christian Rueckert
Research Affiliate
Eugene Lee
Visiting Scientist
Prof. Nancy H Hopkins
Professor of Biology, Emerita