In this talk, I will first discuss the mechanics and general principles to design extreme properties including tough, resilient, adhesive, strong, fatigue-resistant and conductive for soft materials. Then I will discuss a set of soft materials technology platforms, including i). bio adhesives for instant strong adhesion of diverse wet dynamic tissues and machines; ii).bio electronics for long-term multi-modal neural interfaces; iii). Bio robots for teleoperated and autonomous navigations and operations in previously inaccessible lesions such as in cerebral and coronary arteries. I will conclude the talk with a perspective on future human-machine convergence enabled by soft materials technology.