Local Drug Delivery for Facilitating Expedited Urinary Stone Passage

welve percent of men and five percent of women will experience at least one symptomatic urinary stone by age 70. Stones when lodged in the ureter result in extreme pain, nausea, vomiting, ER visits, missed work, and, for some, surgery to remove stones that fail to pass. Over 3.1 million workdays are lost and $5.3 billion in cost is incurred treating stones in the US, annually. This project will develop a locally delivered, outpatient-based therapy offering expedited stone passage.