Principal Investigator Bin Zhang
The maximum entropy approach proposed above enables high-resolution reconstruction of 3D genome structures without explicitly considering the underlying physical principles that organize the genome. To better understand the physical principles of genome organization and to further reveal chromosome structures at a finer resolution on the order of tens of nucleosomes, advanced computational models that allow direct first principle simulations are in need. We are developing protein-DNA models that are both computationally efficient to access the large system size, and chemically accurate to describe specific protein-protein interactions.