Principal Investigator Forest White
Within this framework, a significant fraction of research in the group is centered on the Epidermal Growth Factor Receptor (EGFR) signaling network, quantifying temporal dynamics of protein phosphorylation within the EGFR network while monitoring changes in the network induced by perturbations at the ligand and receptor level. The goal of this research is to answer several questions in oncogenic signaling: how does the EGFR signaling network change when different ligands (e.g. EGF, TGF-alpha, heregulin) are used to stimulate EGFR or EGFR family members, how do mutations within EGFR or over-expression of EGFR family members affect the signaling network, and what role does the EGFR signaling network play in cancer progression?